P-212: Ala 307 Thr Polymorphism of FSHR in Iranian Patients with Polycystic Ovary Syndrome (PCOS)
Authors
Abstract:
Background: Follicle stimulating hormone (FSH) receptor plays an important role in FSH signaling during reproductive development. Any changes in FSHR gene is resulted in alteration of amino acid in protein chain, consequence to affect the binding affinity, intracellular signaling and expression levels of FSHR. FSHR polymorphisms can be involved in etiology of many reproductive disorders such as polycystic ovary syndrome. We aimed to investigate the association of rs6165 polymorphism (Thr307Ala) which can influence the FSH receptor binding affinity to FSH, with Iranian PCOS patients and correlation with drug (exogenous FSH) response. Materials and Methods: A case control study including 90 individuals (30 fertile controls, 30 control 1 and 30 PCOS patients) was performed to investigate the association of SNP rs6165 with drug response in PCO patients. The control group 1 (patients with male factor infertility) and PCO patients were candidates for Intra Uterine Insemination. Polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP) method was implemented on the DNA isolated from blood samples to genotype this SNP. Results: There was significant difference between the percentage of individuals carrying this polymorphism in patients (70%) and control groups (23%). PCO patients with this SNP were shown more response to ovulation induction. Conclusion: There is association between PCOS and rs6165 polymorphism. Further studies are needed to clarify the mechanism of action of this polymorphism. Although, it seems the change of amino acid at position 307 consequences to increase the sensitivity of FSH receptor, which can be considered in ovulation induction of patients to avoid of activeness of OHSS.
similar resources
Treating Polycystic Ovary Syndrome with TCM Polycystic Ovary Syndrome (PCOS)
Women are usually diagnosed when in their 20s or 30s, but PCOS may also affect teenage girls. The symptoms often begin when a girl's periods start. Women with this disorder often have a mother or sister who has symptoms similar to those of PCOS. The main features are obesity, anovulation or amenorrhea, acne, and excessive hair growth. It is thought to be one of the leading causes of female infe...
full textMetabolic Syndrome in Patients with Polycystic Ovary Syndrome in Iran
Background The prevalence of metabolic syndrome (MetS) in polycystic ovary syndrome (PCOS) has been studied in different populations, but their results were so controversial regarding Iranian women. These controversial data indicated the need for more investigation of MetS characteristics in PCOS patients in our population. So this study aimed to evaluate the clinical and laboratory characteris...
full textP-191: Association of STK11 Gene Polymorphisms with Methformin Treatment in Patients with Polycystic Ovary Syndrome
Background: Metformin is an insulin sensitizing drug, which is co-administered with Clominophene citrate or gonadotropins in most cases of polycystic ovary syndrome (PCOS), to improve ovulation. STK11 gene is necessary for action of metformin. Therefore the study of STK11 polymorphisms is important as pharmacogenetics aspects of metformin. The aim of our study was to investigate polymorphism of...
full textChromosomes, Dermatoglyphics and Polycystic Ovary Syndrome (pcos)
Keywords: chromosomal dermatoglyphics genetics infertility Polycystic ovarian syndrome PCOS Original Article Aims: To study and co-relate chromosomal abnormalities and dermatoglyphics in infertile female patients with PCOS. Method: 16 cases of PCOS and 16 normal females as controls were selected. Chromosomal study was done using whole blood culture method and GTG Banding in genetic laboratory. ...
full textPolycystic Ovary Syndrome (PCOS) and Fertility
The polycystic ovary syndrome (PCOS) is defined as a combination of hyperandrogenism (hirsutism and acne) and anovulation (oligomenorrhea, infertility, and dysfunctional uterine bleeding), with or without the presence of polycystic ovaries on ultrasound. It represents the main endocrine disorder in the reproductive age, affecting 6% 15% of women in menacme. It is the most common cause of infert...
full textMy Resources
Journal title
volume 7 issue 3
pages 119- 119
publication date 2013-09-01
By following a journal you will be notified via email when a new issue of this journal is published.
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023